Propylene glycol (C3H8O2) is a clear, colorless and liquid. usually a tasteless, odorless, and colorless clear oily liquid that is hygroscopic and miscible It is manufactured by the hydration of propylene oxide. Propylene glycol contains an asymmetrical carbon atom, so it exists in two. The commercial product is a racemic. Pure optical isomers can be obtained by hydration of optically pure.
Propylene glycol is used as a solvent for intravenous, oral, and topical pharmaceutical preparations It is generally considered safe. However in large doses it can be toxic, especially if given over a short period of time. Intravenous contains the largest amount of propylene glycol of commonly used drugs. In adults with normal liver and kidney function, the terminal half-life of propylene glycol ranges from 1. 4 to 3. 3 hours.
Propylene glycol is metabolized by the liver to form Propylene glycol induced intoxication can also mimic sepsis or systemic inflammatory response syndrome (SIRS). Patients suspected of having sepsis with negative cultures should be evaluated for propylene glycol toxicity if they have been exposed to high dose & other medications containing this solvent.